Special EES Seminar,Thursday January 15th in B01.027
Winter Semester 2025/26
Detlev Arendt
Universität Heidelberg - Germany
Mapping multi-modal single-cell atlases to an electron microscopy volume for an entire animal
Abstract: “Single-cell sequencing data and volume electron microscopy are key to identify and characterise cell types in multicelllar organisms, yet have not yet been combined towards a con´comprehensive genotype-phenotype link. I will present our new efforts to map a whole-body single-cell atlas onto the PlatyBrowser, a multimodal cellular atlas for the marine annelid Platynereis dumerilii. We learn that large sets of co-expressed genes map to eight major celllular morphotypes, or tissues, in the body representing epidermis, digestive tissue, vasulature, contractile tissue, glia, ciliated cells, glands, or neurons. Our new resource closely matches the cellular genotype-phenotype link and, in combination with single-cell ATACseq data, can be used to understand how the genome is translated into cellular and organismal phenotypes."
Prof. Dr. Detlev Arendt is a group leader and Senior Scientist at the Developmental Biology Unit at the European Molecular Biology Laboratory in Heidelberg and holds a honorary professorship at the Centre for Organismal Studies at Heidelberg University. His laboratory has established the marine annelid Platynereis dumerilii as a molecular model for evolutionary, developmental and neurobiological research, with a major interest in the evolution of animal body plans and nervous systems. He has studied the evolution of photoreceptor cells and pioneered the new field of cell type evolution and development. He has received two consecutive European Research Council Advanced Grants and is a member of the European Molecular Biology Organization and of the Academia Europea.
Host: Jochen Wolf
Previous and future talks in the EES seminar series